若手国際交流プログラム　Asian Biological Psychiatry Symposium

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若手国際交流プログラム Asian Biological Psychiatry Symposium

AS-1 Structural Neuroimaging findings in patients with panic disorder Lee Sang-Hyuk Department of Psychiatry, Bundang CHA Medical Center CHA University School of Medicine 351 Yatap, Bundang, Seongnam, Kyounggi, Republic of Korea. Structural neuroimaging have showed the possibility of brain structural abnormalities in patients with panic disorder（PD）. A relative increase in gray matter volume was found in the insula of PD patients compared with controls. Additional structures showing differential increases were the left superior temporal gyrus, the midbrain, and the pons. A relative gray matter deficit was found in the anterior cingulate cortex. Gray matter density of the left parahippocampal gyrus was significantly lower in patients with panic disorder compared with healthy subjects. Also PD patients exhibited significantly greater fractional anisotropy（FA）values in WM regions including left anterior and right posterior cingulate regions relative to Healthy control（HC）subjects that was also positively correlated with clinical severity. However, A diffusion tensor imaging（DTI）study showed decreased FA in frontal WM and WM around the frontal lobe, including the corpus callosum of both hemispheres in PD patients compared to HC subjects. And, the alteration of WM connectivity was also associated with the comorbid conditions in PD patients. Compared to the PD patients without comorbid major depression group, FA values were significantly higher across almost all the WM tracts in the PD with comorbid major depression group. Previous TBSS analysis showed increased FA in posterior thalamic radiation, posterior and superior corona radiata, superior longitudinal fasciculus, and sagittal stratum, all located in the right hemisphere in catechol-O-methyltransferase gene val158met polymorphism（rs4680）AA/AG genotype group compared to GG genotype in PD. In the case of serotonin-1A receptors polymorphism（rs6295）, the TBSS analysis showed significantly increased FA values in cingulate gyrus process of left cingulum in CC genotype compared to GG/CG genotype in PD. These preliminary studies suggest that the genetic polymorphism also may be associated with WM connectivity in PD.		AS-2 Change of plasma adiponectin level after smoking cessation Won Wangyoun 180, Wangsanro, Dongdaemungu, Seoul, Korea Department of Psychiatry, St. Paul's Hospital, The Catholic University of Korea Objective：Cigarette smoking is associated with a variety of health problems including cardiovascular, pulmonary, neoplasms, endocrinopathies including diabetes, the metabolic syndrome, and chronic inflammation. Adiponectin is an adipocyte-derived plasma protein that is closely associated with insulin sensitivity and the metabolic syndrome. The aim of this study was to evaluate the changes of plasma adiponectin levels after smoking cessation. Methods：Thirty seven smokers that wanted to stop smoking without any nicotine replacement therapy or medication were recruited for this study. Fifteen smokers succeeded in stopping smoking（validated by urine cotinine levels ≤50 ng/mL）and 22 smokers failed. Therefore, only the 15 that succeeded were included in the analysis. The plasma adiponectin levels were determined using a commercially available enzyme-linked immunosorbent assay. Results：The mean age of the successful 15 was 35±9.3 years old. They were all males. The daily smoking habit was a mean of 13.5±5.4 cigarettes per day. The mean Nicotine Dependence Syndrome Scale（NDSS）andFagerstrom Test for Nicotine Dependence（FTND）scores were 55.6±9.6 and 2.9±1.9. During the study period of three months, the mean body mass index（BMI）, body fat mass（BFM）, waist-hip ratio（WHR）and body weight increased by 1.1kg/m2, 3.0%, 0.02%, and 2.9kg, respectively. The baseline mean adiponectin level in the subjects was 11.9±5.2 mg/L. The mean adiponectin levels measured at one and three months were 16.0±5.1 mg/L and 14.7±4.5 mg/L respectively. The mean plasma adiponectin levels of the successful group was significantly increased after four weeks when compared to the baseline（z=-2.401, p=0.016）. However, the decrease in plasma adiponectin levels at one and three months was not statistically significant. Conclusion：Even though the decrease over the next two months was not significant, these findings, the increase of plasma level of adiponectin after smoking cessation, provide preliminary data for future research on the possible mechanisms associated with smoking cessation and changes in body metabolism.

AS-3 Attention deficit hyperactivity disorder, tic disorder, and allergy：is there a link? A nationwide population-based study Mu-Hong Chen Department of Psychiatry, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan Background：Attention deficit hyperactivity disorder（ADHD）and tic disorder usually co-occur in the same individuals, but the underlying mechanisms remain unclear. Previous evidence has shown that a frequent coexistence of allergic diseases was noted in patients with ADHD or tic disorder. We attempted to investigate the possible link among ADHD, tic disorder, and allergic diseases. Methods：Utilizing the Taiwan National Health Insurance Research Database, 5,811 patients with ADHD alone, 1,816 patients with tic disorder alone, and 349 patients with dual diagnoses of ADHD and tic disorder were identified and compared with age-/gender-matched controls（1：4）in an investigation of the association among ADHD, tic disorder, and allergic diseases. Results：Patients with ADHD and tic disorder had a significantly higher prevalence of allergic diseases and psychiatric comorbidities, including allergic rhinitis（43% vs. 28.4% vs. 33.6% vs. 19.7%, p＜0.001）, asthma（27.5% vs. 17.2% vs. 18.2% vs. 11.9%, p＜0.001）, atopic dermatitis（10.6% vs. 8.4% vs. 7.0 vs. 5.9%, p＜0.001）, allergic conjunctivitis（55.6% vs. 34.7% vs. 43.5% vs. 26.3%, p＜0.001）, obsessive compulsive disorder（4.0% vs. 1.3% vs. 2.0% vs. 0.1%, p＜0.001）, and anxiety disorder（22.1% vs. 18.0% vs. 6.0% vs. 0.5%, p ＜ 0.001）than the ADHD alone group, the tic alone group, and the control group. Furthermore, ADHD patients with more allergic diseases（≧3 comorbidities：OR：3.73, 95% CI：2.65～5.25；2 comorbidities：OR：2.52, 95% CI：1.82～3.47；1 comorbidity：OR：1.87, 95% CI：1.41～2.49）exhibited an increased risk of tic disorder compared with ADHD patients without allergic disease. Conclusion： A significant association among ADHD, tic disorder, and allergic diseases was noted in our study. The results may inspire further studies to clarify the underlying mechanisms and help us understand more about the complex etiology of ADHD, tic disorder, and their co-occurrence.		AS-4 Oxytocin receptor gene rs53576 polymorphism modulates oxytocin―dopamine interaction and neuroticism traits―A SPECT study Hung Chang Wei 704 No.138, Sheng Li Road, Tainan, Taiwan 704, R.O.C Brain oxytocin and dopamine systems interact to modulate social cognitive behavior. Whether the interactions are modulated by oxytocin receptor（OXTR）gene variations remains unclear. Considering the dopamine transporter（DAT）availability as an endophenotype and the degree of dopamine-mediated neuroticism as a phenotype of the OXTR genotypes, the current molecular imaging study used[99mTc]TRODAT-1 single photon emission computed tomography（SPECT）to measure the striatal DAT availability and the 57-item Maudsley Personality Inventory to measure neuroticism personality traits in healthy individuals to investigate（A）the correlation between the rs53576（G/A）of OXTR and the striatal DAT availability, （B）the correlation between the peripheral oxytocin level and striatal DAT availability among different OXTR rs53576（G/A）genotypes, and（C）whether neuroticism traits could be modified by oxytocin in certain OXTR rs53576 genotypes. The results showed that the striatal DAT availability in the AG+GG group was significantly lower than that in the AA group（2.08±0.47 vs.1.90±0.32, p=0.04）. Only individuals with one or two copies of the G allele of rs53576 showed a negative correlation between DAT availability and oxytocin level（r=－0.41, p=0.002）. Furthermore, the oxytocin×DAT interaction was significantly correlated with the MPI neuroticism score in the AA group. Further analyses showed that the DAT availability was correlated with the neuroticism score only in the AA group with a low oxytocin level（r=0.74, p=0.002）. The results indicated that the OXTR rs53576 is connected with the striatal DAT availability in vivo and modulates the interactions between the oxytocinergic and dopaminergic systems. Carriers with a specific rs53576 OXTR genotype may present a greater biological sensitivity as well as stress reactivity in terms of environmental adaptation.