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An outsider’s take on autism spectrum disorders
Raff Martin
MRC LMCB, University College London
Autism spectrum disorders（ASDs）are among the commonest neuropsychiatric disorders. Although, until recently, ASDs were one of the least understood of these disorders, they are now one of the best understood. Progress has come largely through recent advances in human genetics that have identified rare large-effect mutations that cause or greatly increase the risk of these disorders, together with studies of genetic mouse models based on these mutations. Remarkably, in a number of mouse models caused by single mutations, correction of the problem in the adult brain（with either drugs or genetic manipulations）largely reverses many of the behavioral and neurobiological abnormalities, providing hope for the development of therapies for individuals with ASDs. In my talk, I will review the basic features of ASDs, using home videos of the development of my 13-year-old autistic grandson as an example, and I will discuss some of the recent advances in ASD research, consider current puzzles, and speculate on possible ways forward. | | | |
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