WD8-1
Suppressed high gamma activity during emotion regulation
情動制御とガンマ帯域神経活動
Nakanishi Shoichiro（中西 翔一郎），平野 羊嗣，鬼塚 俊明，神庭 重信
Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
Introduction:Abnormal emotion regulation is one of the critical problems often encounters in clinical practice when treating psychiatric patients. However, less is know for its underling neural basis.Thus, we performed EEG spectral analysis for a better understanding of the brain activities during emotion regulation.Method:EEG was recorded using 64 electrodes (BioSemi ActiveTwo) from 34 healthy subjects (mean age: 20.7, 10 males, 24 females) during exposed to either unpleasant or neutral images quoted from the International Affective Picture System (IAPS). Subjects were instructed to either just attend or suppress emotional expression during exposed to the images. EEG time-frequency analyses were performed with MNE-python (www.martinos.org/mne). EEG signals were corrected for eye movements, blinks and other confound noise using ICA. The wavelet transform was applied to the EEG signals and induced power within the high gamma-range (70 to 90 Hz) after stimulus onset (0.5 to 3.5 sec) at Fz and FCz electrodes were calculated.Results:A significant interaction for emotion regulation and image types(p = 0.008) within the high gamma activity was observed.Furthermore, during exposed to unpleasant images, high gamma activity was significantly suppressed (p = 0.0007) with emotion regulation condition when compared to attended condition.Discussion:Recent studies have revealed tight relation between gamma band activity and various sensory/cognitive processing, but to our knowledge, this is the first study suggesting the link between high gamma activity and emotion regulation, which might be useful in clinical practice through neurofeedback technics. | | WD8-2
Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study
てんかん精神病の神経基盤：MRI研究
Hirakawa Noriaki（平河 則明），平野 羊嗣，鬼塚 俊明
The department of neuropsychiatry, University of Kyushu, Fukuoka, Japan
Background: Schizophrenia and chronic interictal epileptic psychosis (EPS) are thought to have different underlying pathophysiological mechanisms. The current study was conducted to investigate the neural basis of EPS.Methods: T1-weighted images were analyzed in 16 patients with EPS, 16 strictly-matched patients with epilepsy only (EP) and 16 healthy control subjects (HS). We conducted structural magnetic resonance imaging (MRI) using a manual drawing method with regions of interest (ROIs) including the hippocampus, amygdala, Heschl’s gyrus, and planum temporale. In addition, we conducted volume comparison in the whole brain using voxel-based morphometry (VBM) to compare the EP and EPS groups.Results: Manual ROI results revealed that both epilepsy groups exhibited significantly reduced bilateral hippocampal volumes compared with HS (p = 0.008). The exploratory analysis of the whole brain using the VBM method revealed that EPS patients exhibited significantly reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus compared with EP patients (p = 0.029, FDR corrected).Conclusions: The results of ROI analyses indicated that the hippocampus, amygdala, Heschl’s gyrus, and planum temporale may not be crucial for generating EPS. VBM analysis suggested that reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus may be crucial for EPS. |
