Symposium
Revolutionizing the screening process of mid-sized molecular drugs
シンポジウム
特殊ペプチド創薬：中分子薬剤スクリーニングの革命 |
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| 7月25日（木）15:40～16:40 第10会場（万代島ビル 6F 会議室）
1S10a
特殊ペプチド創薬：中分子薬剤スクリーニングの革命
Hiroaki Suga（菅 裕明）
東京大学大学院理学系研究科
Macrocyclic peptides possess a number of pharmacological characteristics distinct from other well-established therapeutic molecular classes, resulting in a versatile drug modality with a unique profile of advantages. Macrocyclic peptides are accessible by not only chemical synthesis but also ribosomal synthesis. Particularly, recent inventions of the genetic code reprogramming integrated with an in vitro display format, referred to as RaPID (Random non-standard Peptides Integrated Discovery) system, have enabled us to screen mass libraries (>1 trillion members) of non-standard peptides containing multiple non-proteinogenic amino acids, giving unique properties of peptides distinct from conventional peptides, e.g. greater proteolytic stability, higher affinity (low nM to sub nM dissociation constants similar to antibodies), and superior pharmacokinetics. The field is rapidly growing evidenced by increasing interests from industrial sectors, including small start-ups as well as mega-pharmas, toward drug development efforts on macrocyclic peptides, which has led to several de novo discovered peptides entering clinical trials. This lecture discusses the aforementioned screening technology, the RaPID system, and several showcases of therapeutic potentials of macrocyclic peptides. This lecture also discusses an application of the RaPID peptides to biologics development. | | | |
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