WD11-1
Decline in handgrip strength from midlife to late-life is associated with dementia: the Hisayama Study
地域高齢者における中年期から老年期の握力低下と認知症発症の関連：久山町研究
Hatabe Yozo（畑部 暢三）1，小原 知之1，神庭 重信1，二宮 利治2
1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
2Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Objective To clarify the association between the decline in handgrip strength from midlife to late-life and the development of total dementia, Alzheimer disease (AD), and vascular dementia (VaD) in a general elderly population.MethodsA total of 1,055 community-dwelling elderly people aged 60 to 79 without dementia (mean age, 68 years) were followed prospectively for 24 years (1988 to 2012). Among them, 835 subjects participated in a health examination conducted in 1973-1974 (mean age, 53 years) and were included in the analysis of midlife. The risk estimate of the decline in handgrip strength from midlife to late-life on the development of dementia was assessed using a Cox proportional hazards model. Results During the follow-up, 368 subjects experienced total dementia. The age- and sex-adjusted incidence of total dementia increased significantly with greater decline in handgrip strength (increase [/>+0%] 25.1, mild decrease [-14 to -1%] 28.4, and severe decrease [/< -15%] 38.9 per 1,000 person-years). Greater decline in handgrip strength was significantly associated with higher risk of total dementia after adjusting for potential confounding factors; subjects with severe decrease in handgrip strength had 1.47-fold (95% confidence interval (CI) = 1.11-1.95, p = 0.01) increased risk of total dementia than those with increase in handgrip strength. Similar significant findings were observed for AD, but not for VaD. Conclusions Our findings suggest that greater decline in handgrip strength from midlife to late-life is an important indicator for late-life onset of dementia.This study was approved by the Kyushu University Institutional Review Board for Clinical Research. We obtained written informed consent from the participants. | | WD11-2
Effect of educational attainment on Alzheimer's disease-related neuroimaging biomarkers in healthy controls, and participants with mild cognitive impairment and Alzheimer's disease
アルツハイマー病における教育期間が神経画像バイオマーカーに与える影響
Wada Masataka（和田 真孝）1，野田 賀大1，品川 俊一郎2，澤田 恭助1，尾久 守侑1，垂水 良介1，津川 幸子1，山縣 文1，宮崎 貴浩1，三村 將1，中島 振一郎1
1Department of Neuropsychiatry, Keio University School of Medicine
2Department of Psychiatry, Jikei University School of Medicine
Background: Cognitive reserve is the acquired capacity reflecting a functional brain adaptability/flexibility in the context of aging. Educational attainment is thought to be one of the most important contributors to cognitive reserve.
Objective: The goal of this research is to examine the relationships among duration of education and Alzheimer's Disease (AD) related neuroimaging biomarkers such as amyloid-β deposition, glucose metabolism, and brain volumes in each stage of AD.
Methods: We reanalyzed a part of the datasets of the Alzheimer's Disease Neuroimaging Initiative. Participants aged from 55 to 90 (inclusive) years old and diagnosed with mild cognitive impairment (MCI) or AD, as well as healthy controls (HC). Multiple regression analyses were conducted to investigate the relationships among duration of education and amyloid-β deposition (n=825), brain metabolism (n=1304), and brain volumes (n=1606) among three groups using data for 18F-Florbetapir (AV-45) imaging, Fludeoxyglucose (FDG) Positron Emission Tomography, and T1-weighted magnetic resonance imaging.
Results: Duration of education had no correlations with amyloid-β deposition or brain metabolism in any groups. However, duration of education was positively associated with the total brain volume only in participants with MCI.
Conclusions: Our findings suggest that education may exert a protective effect on total brain volume in the MCI stage but not in HC or AD. Thus, education may play an important role in preventing the onset of dementia through brain reserve in MCI. |
