| 特別講演1 |
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| 2021/9/30 9:00～10:00 ZOOM A会場
PL1-1
Muscarinic receptors as therapeutic targets for alcohol use disorder
○J,Lawrence, Andrew
Professor NHMRC Principal Research FellowDivision Head, Florey Institute of Neuroscience &MentalHealth,University of Melbourne
Despite the large socioeconomic burden of alcohol use disorders (AUD), therapeutic treatment options are limited. There is a need to characterise the underlying neurochemistry driving alcohol seeking to identify and evaluate novel targets. Muscarinic acetylcholine receptors (mAChRs) are expressed within the mesocorticolimbic reward system, including dense expression in the striatum, where they modulate dopamine and glutamate release, which may regulate reward processing. We have undertaken a multidisciplinary approach, examining gene and protein expression in post-mortem human brain tissue and developing rodent models that recapitulate our molecular findings from humans with AUD. These studies implicate mAChRs as potential novel therapeutic targets, including functional evidence in preclinical studies. I will discuss our recently published (Walker et al 2020; Berizzi et al 2018) plus currently unpublished data to highlight our interest in this system.
・Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents. Walker LC, Berizzi AE, Chen NA, Rueda P, Perreau VM, Huckstep K, Srisontiyakul J, Govitrapong P, Xiaojian J, Lindsley CW, Jones CK, Riddy DM, Christopoulos A, Langmead CJ, Lawrence AJ.
Biol Psychiatry. 2020 88(12):898-909
・Muscarinic M5 receptors modulate ethanol seeking in rats.
Berizzi AE, Perry CJ, Shackleford DM, Lindsley CW, Jones CK, Chen NA, Sexton PM, Christopoulos A, Langmead CJ, Lawrence AJ.
Neuropsychopharmacology. 2018 43(7):1510-1517.
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