| 日本神経化学会優秀賞受賞講演 |
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| 7月8日（土） 13:50-14:50 Room F
脳内マクロファージの統合的理解に向けた研究
Research towards an integrated understanding of brain macrophages
増田 隆博
九州大学生体防御医学研究所分子神経免疫学分野
Takahiro Masuda
Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University
The central nervous system (CNS) host a variety of immune cells, which carry out various functions during not only development and homeostasis, but in disease conditions. Macrophages in the CNS comprise two anatomically distinct populations: microglia are located in the parenchyma, and CNS border-associated macrophages (CAMs) are found in CNS interfaces including the meninge, and perivascular space. Both populations contribute to a specialized and tightly regulated resident immune system in the CNS. Accumulating evidence has shown that microglia play a variety of biologically important roles—such as supporting neurogenesis, synaptic pruning, scavenging for dying cells in the CNS. In addition, the recent emergence of novel technologies, such as single-cell RNA sequencing and fate mapping, has enabled to study microglia and CAMs in depth. Here, I will discuss our current knowledge of the origins, kinetics, functions, transcriptomic profiles, heterogeneity of microglia and CAMs and how those macrophages regulate the CNS environment. | | | |
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